I ran Starcraft 2 through Lutrus and it was a piece of cake. No lag that I could discern. There was a little mini launcher and everything. The multiplayer also worked just fine, although the matchmaking system seemed to think I was an expert level player for some reason and kept matching me with dudes who were way better at the game than I was.
To me, this is the one thorn in Linux (and the Linux online community) that gives me pause.
For the people that it just works for, well it just works for.
For anyone else, apparently they are the problem? Not Linux?
Well sorry no. I did get StarCraft 2 working with Lutris... once. Then I couldn't get it to start again. Eventually I switched to running Battle.Net from Steam and for some reason that did work. But it wasn't a "just works" or "piece of cake." It was a puzzle.