Very interesting. It would be great if this works with a "higher" level library like Pixi.js or Phaser.js, that way one could build with ease in JS/TS, using a rich library/ecosystem and still distribute a "native" app (it probably already works with these libs but not sure).
Phaser is not supported right now because phaser is still using a WebGL renderer from my understanding (maybe in a v2.0.0 adding ANGLE + WebGL support is an option, but debating if that's a good idea or not).
Pixi 8 has a WebGPU renderer so that should be supported as part of a v1.0.0 release - it's on the roadmap to verify that three and pixi 8 work correctly: https://github.com/mystralengine/mystralnative/issues/7