Personally, I keep things simple. Got a new (pretty basic) Honeywell thermostat after a kitchen fire; thermostat was pretty old anyway. For wiring, you mostly have 2-wire and 3-wire although there are a lot of variations as you get fancier: https://nassaunationalcable.com/blogs/blog/a-full-guide-to-t...

Number of zones in the house may affect things as may boiler only or AC being in the picture as well.