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olivia-bankstoday at 12:26 AM1 replyview on HN

> Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments

https://journals.plos.org/plosone/article?id=10.1371/journal...

In theory, it's very much doable. We brought back an extinct cowpox virus a while ago using mail-order DNA. Did you know that Smallpox's nucleotide sequence is freely available online?


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XorNottoday at 12:58 AM

You're going to have to link that for me because I know the longtermism people are nuts about this, but their actual understanding is pretty poor.

There's a gulf between assembling a vaccine - which is a commonplace technology, and assembling a viable infectious viral particle.

Being able to order all the oligos of a viral sequence isn't even step 1.

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