You can choose to exclude Safari from these protections[0]. Honestly, looking at the list of "limitations" you'll have while running Lockdown mode, I'm surprised most of them aren't the system default.
[0] https://support.apple.com/en-us/105120 - under "How to exclude apps or websites from Lockdown Mode"
Sure but the JIT js disable and limiting of image/video decoders are combined basically all the security from lockdown mode, so disabling it seems pointless.