For me, it depends on how well-disguised the ad is. Ads quietly sitting there, informing? Those I blank out. The big flashy animations? Those make me switch to reader mode, or leave the domain entirely.

I do sometimes find I'm accidentally clicking on the ads at the top of search engine results, though for this case it's extra ironic as the ad is for the real thing I'm searching for which is 2 results further down the list, and I only realise I clicked on an ad when the link goes via an ad-tracking domain that I block.

I've recently been fooled by an ad in reddit that was pretending to be news, which took me to a fake BBC website. First hint, I also block the BBC domain (nothing wrong with them, it's just a habit I want to get out of given I don't live in the UK any more).