ER=EPR says something completely shocking about the nature of the universe. If there is anything to it, we have almost no clue about how it works or what its consequences are.
Sean Carroll's own favorite topics (emergent gravity, and the many worlds interpretation) are also things that we don't have any clue about.
Yes there is stuff we can calculate to very high precision. Being able to calculate it, and understanding it, are not necessarily the same thing.