GLP-1 drugs carry a small risk of gastroparesis, which can be severe in some patients. I wouldn't recommend avoiding using them due to that risk if medically indicated but patients should be aware.

https://www.centraloregondaily.com/news/consumer/glp-1-weigh...

Stomach paralysis is apparently a known side effect [1]. There are also lots of anecdotes about lesser (but still foul) digestive surprises that are too unpleasant for me to bother elaborating on here.

I was on my thiccboi swag for the latter half of last year and am presently working it off by rebuilding my fitness base with kettlebells and cardio. I'd rather do this than GLP-1s not because I'm some sort of iron-willed badass so much as I'm simply distrustful of anything that messes with one's metabolism so severely. While these drugs are useful for the morbidly obese and diabetics I simply can't imagine how or why anybody would go on them for aesthetic or off-label purposes.

[1] https://www.webmd.com/obesity/ozempic-and-stomach-paralysis

To be fair, we have seen some long term effects from antibiotic use. Especially with regards to gut biomes. However, the long term effect of not using them is oftentimes death or permanent disability. Don't see nearly as many amputations from infected scratches these days thankfully.

Or like Vitamin C. There aren’t side effects to fixing a vitamin deficiency. This increasingly, to me, looks like that. (There are absolutely bad effects from overdoing it.)