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CGMthrowawayyesterday at 10:24 PM1 replyview on HN

Sublingual is even harder. The sublingual mucosa is thin but selective. It strongly favors molecules that are small, lipophilic and uncharged. Semaglutide is about 8-10x too big, highly polar and charged.

Injection is really the only method with any substantial bioavailability. BUT, low (<1%) bioavailability does not necessarily mean useless.


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cassepipeyesterday at 11:32 PM

> BUT, low (<1%) bioavailability does not necessarily mean useless.

Can you say more about that point ?

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