The solution, if you want a production ready GUI, is to use a GUI toolkit which already has decent accessibility support.

There aren't that many of those: .NET, AppKit/UIKit, SwiftUI, Qt, GTK, the web, wxWidgets (which is really just GTK/AppKit/.NET), probably a couple others. So you either use the native language of one of those toolkits, or you use bindings from your language to those toolkits.