As someone that hosts and co-hosts several game nights (once or twice a week, most weeks), the key is to try to feel out the group, and if necessary/helpful/desired, send out "how to play" videos in advance (if they prefer learning that way vs. live).
But yeah, see if the group wants to learn a new one vs. playing one they already know.
When I set up games for my coworker group, I always send out new options along with a number of games we've already played, and let them pick. (More times than not, they pick a new game.)
When I host games with my family, I always bring a bunch of games, both new and already played, and let them pick (these are usually much lighter [easier] games). I'll sometimes suggest a new game if I think they'll like it, and they usually do. The key is to get to know what the group typically enjoys.