Difficulty is the only true moat. [Astronaut: always has been]

Current examples: esoteric calculations that are not public knowledge; historical data that you collected and someone else didn't; valuable proprietary data; having good taste; having insider knowledge of a niche industry; making physical things; attracting an audience.

Some things that were recently difficult are now easy, but general perception has not caught up. That means there's arbitrage—you can charge the old prices for creating a web app, but execute it in a day. But this arbitrage will not last forever; we will see downward price pressure on anything that is newly easy. So my advice is: take advantage now.