We have a similar use case. All Elixir code base, but need to use Python for ML libraries. We decided to use IPC. Elixir will spawn a process and communicate over stdio. https://github.com/akash-akya/ex_cmd makes it a breeze to stream stdin and stdout. This also has the added benefit of keeping the Python side completely stateless and keeping all the domain logic on the Elixir side. Spawning a process might be slower compared to enqueuing a job, but in our case the job usually takes long enough to make it irrelevant.