I can speak anecdotally, at least.

My shoulders are pretty wide for my frame. When using most laptop keyboards and many standard keyboards, I have to tuck my shoulders in and twist my wrists. This was causing some serious pain and tension in my neck, shoulders, and wrists, likely leading toward carpal tunnel.

I made two different changes in succession that helped greatly (and I don't remember the order now):

1. With a split keyboard, the halves could be placed so my wrists are straight and my arms hold at shoulder-width, and this rapidly reduced the amount of tension I was experiencing and gradually eased my wrist issues. Tenting the keyboard and getting a vertical mouse helped as well, but I'd rate those as minor improvements, especially since I aim not to drive with the mouse as much.

2. With Colemak layout, I was able to gradually transition from QWERTY (there's a series of AHK scripts I found at the time that basically rotated triples of keys). This helped reduce wrist strain at the hand level.