Ireland is solid, especially for any sort of biotech/medical. Strong critical skills immigration path, good wages, pretty much every major company has a facility there (many rivaling the US sites in size), friendly and welcoming place. Housing is a bit of struggle, mainly for renters.
I made the leap this year. No regrets.
Tell me more. As someone with dual Canadian/US citizenship (former EU citizen that I gave up 20+ years ago) - how hard is it to get in?
Irish infra is not great if you compare it to many advanced European countries. I hate they still do not have a train/tram connection from the airport to the city. Taxes also make you weep. Not to mention an immense risk of losing all those corp taxes and industry if US pushes ahead and creates barriers for companies to trade. It is great at many things but also has some downsides.