I forget the name of the layout (the board is a Lily58), but my keyboard does away with the staggered key spacing and has keys aligned vertically with a subtle bowling. You're usually pressing keys with your pad, not the sides or tips, and I suspect it would be even better with flat low profile keycaps.

There are some styles of "chording" keyboards that might help too, and some that would be way worse. Chording keyboard are also wildly different to regular keyboards, totally alien by comparison to just splitting a keyboard.