For me, as a two thumb typer, I feel like if you had kept the letters generally on the same side (left/right) as Qwerty, even if nowhere near the same location, I could adapt to it much more quickly.
I go to spell something as simple as my name on this and none of the keys are anywhere near where 40 years of muscle memory expect.
Frankly, I just want to hit the letters with the same thumb.
I understand not wanting to copy, to be a purely original creation, but you could certainly help adoption by making it a little less painful.