I don't think that's possible in Mexico. There's too much power in the logistical networks that move things into the US. The demand is too great. Even if you kill every drug trafficker and gang member alive today and create huge prosperity the void will be filled by someone and they will be adversarial to the government and they will have to use extra judicial violence to enforce their position.

The cartel's presence in Mexico is extremely muted relative to their power.