Bit of googling suggests this is a whole, fascinating world of little improvements. However it's also both constrained and pushed forward by what's road legal.
https://www.volvotrucks.co.uk/en-gb/news/insights/articles/2... : removing mirrors allows for much smoother cab airflow
https://go2stream.com/blog/aerodynamic-truck-legislation-rea... : UK legalization of fishtail-like devices
https://www.kudauk.ltd.uk/aerodynamics-explained : Kuda on the UK allowing higher loads, and therefore benefiting from extra wedge devices on the top of the cab.
I'm sure there's a lot more out there. The eventual switch to electric will probably come with another round of aerodynamic improvements to maximise range, as with cars.
> removing mirrors allows for much smoother cab airflow
On brand new trucks (designed without mirrors) yes. However on older trucks the mirror design might be an essential part of the aerodynamic design and required for a low drag coefficient.