Liver exerkine reverses Alzheimer's-related memory loss via vasculature

Blood factors transfer the benefits of exercise to the aged brain independent of physical activity. Here, we show that the liver-derived exercise factor (exerkine) glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-degrading enzyme, reverses aging- and Alzheimer's-related memory loss by targeting the brain vasculature.

https://pubmed.ncbi.nlm.nih.gov/41713415/

40 hz ultrasound waves do that too. Read about David Orenstein, Stuart Hameroff, Anirban's related papers on microtubules and fractal frequencies.

https://news.mit.edu/2025/study-suggests-40hz-sensory-stimul...

In mice.