To save others a search, here's the podcast with Wolfram.

Stephen Wolfram on Computation, Hypergraphs, and Fundamental Physics - https://podbay.fm/p/sean-carrolls-mindscape-science-society-... (2hr 40min)

I'm a fan of his work and person too. Not a fanatic or evangelical level, but I do think he's one of the more historically relevant computer scientists and philosophers working today. I can overlook his occasional arrogance, and recognize that there's a genuine and original thinker who's been pursuing truth and knowledge for decades.