Qt45: A small polymerase ribozyme that can synthesize itself

Quinozyme

It's interesting, that we're getting down to the sizes of self-replicating RNA that realistically can form by a complete accident.

Getting this sequence by random chance out of a pile of nucleotides is a 1 in 2^90 chance. That's around 1.2*10^27 or just around 20000 moles! Not at all an impossible number.

2009 paper: Self-sustained replication of an RNA enzyme [0].

[0] https://pubmed.ncbi.nlm.nih.gov/19131595/

See also: Spiegleman's Monster

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