Is this the first company to actually face to face stand up to the current administration?
No, a few law firms targeted by EOs fought them in court last year and won.
The usual suspects have stood up to it. Ben & Jerry's, Patagonia. In the former case it led to an illegal takeover by Unilever for which they're now being sued (or more accurately, the spinoff). Capgemini sold a US division over working with ICE, though that's a French company.
So yeah, extremely few have.
Harvard is an analogue in the academic sphere, if you include organizations beyond just companies.
The Supreme Court decision striking down IEEPA tariffs was from a number of small businesses standing up against the current administration. [1]
[1] https://en.wikipedia.org/wiki/Learning_Resources,_Inc._v._Tr...
Hundreds of companies have filed lawsuits against the admin over the tariffs.
Costco has been. When every other major company was scuttling their DEI initiatives Costco doubled down. Doesn’t seem to have impacted them yet.