There are plenty of physical and legal barriers to creating a bioweapon and that's not going to change if everyone becomes smarter with AI. And even if we really somehow end up in a world where everyone has a lab at home and people can easily create viruses, they can also easily create vaccines and anti-virals. The advancements in medicine will outpace bioweapons by a lot because most people are afraid of bioweapons.
Intelligence itself is not dangerous unless only a few orgs control it and it's aligned to those orgs' values rather than human values. The safety narrative is just "intelligence for me, but not for thee" in disguise.
There mostly aren't physical barriers. Unlike nukes, where you need specific materials and equipment that we can try to keep tabs on, bioweapons can be made entirely with materials and equipment that would not be out of place in an academic or commercial lab. The largest limitation is knowledge, and the barriers there are falling quickly.
On your second point, see my response to oceanplexian below: https://news.ycombinator.com/item?id=47189385