If you care about space, you're almost certainly going to compress your output (unless, like, you're literally storing random noise) and so you'll necessarily have overhead from that.

Unless the reason you care about space is because it's some sort of wire protocol for a slow network (like LoRaWAN or Iridium packets or a binary UART protocol), where compression probably doesn't make sense because the compression overhead is too large. But even here, just defining the data layout makes sense, I think.

Tihs could take the form of a C struct with __attribute__((packed)) but that is fragile if you care about more platforms than one. (I generally don't, so that works for me!).