Third party libraries like SciPy scikit-learn, pandas, tensorflow and pytorch have been critical to python’s success. Since CPython is written in C and exposes a nice C API, those libraries can leverage it to quickly move from (slow) python to (fast) C/C++, hitting an optimum between speed of development and speed of runtime.

PyPy’s alternative, CFFI, was not attractive enough for the big players to adopt. And HPy, another alternative that would have played better with Cython and friends came too late in the game, by that time PyPy development had lost momentum.