Assuming you mean this crash [0], it reads to me more like a confluence of bad events versus a big fundamental design flaw in the THERAC-25 mold.

I feel the current proliferation of LLMs is going to resemble asbestos problem: Cheap miracle thingy, overused in several places, with slow gradual regret and chronic harms/costs. Although I suppose the "undocumented nasty surprise" aspect would depend on adoption of local LLMs. If it's a monthly subscription to cloud-stuff, people are far less-likely to lose track of where the systems are and what they're doing.

[0] https://en.wikipedia.org/wiki/Air_France_Flight_4590