I like Simutrans more because the cargo and passengers have destinations in mind.
TTD and OpenTTD do not which incentivizes mechanisms to dump everyone at the edge of the map.
Aside from that they're both transport games with bad UIs.
Why the simutrans folks decided on a weird hardcoded frame rate (40fps) that looks janky as hell on every single display ever I will never understand. Unplayable. instant motion sickness.
OpenTTD has the `cargodist` option which simulates reality more closely. Passengers enter stations with a destination in mind and will transfer at other stations.