I remember Buenos Aires to Porto Alegre (via Foz do Iguaçu) by bus. I guess that's about 1/4 or 1/3 as far, with somewhat less dramatic landscapes. Extremely comfortable except for the violent action movies shown on an overhead TV with sound, even for part of the night.
Edit: but ultimately probably a very different experience because it's so much less mountainous!
That’s basically just a bus up the coast of Uruguay and a bit of Rio Grande do Sul? I did the same route in the opposite direction, via Tacuarembo, mostly on horseback. Extremely uncomfortable, but an interesting week nonetheless.