It's going pretty well, though it took at least six months to get there. I'm helped by knowing the domain reasonably well, and working with a principal investigator who knows it well and who uses LLMs with caution. At this stage I use Claude for coding and research that does not involve sensitive matters, and local-only LLMs for coding and research that does. I've gradually developed some regular practices around careful specification, boundaries, testing, and review, and have definitely seen things go south a few times. Used cautiously, though, I can see it accelerating progress in carefully-chosen and -bounded work.