alt Hacker NewsECT just comes across as a bit barbaric. I'd welcome more research into Psilocybin to achieve system reset.
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People do try psylocybin, or ketamine, or frankly just about anything. Esketamine even has regulatory approval as a tretment. Research is sometimes posted here on HN. But nothing seems to be as effective as ECT, it truly is the king of affective disorders.
BTW, and not many people know this, it is a procedure performed under full anesthesia, including muscle blockers. From the outside it looks very calm, and from the inside the patient's experience is pretty much identical to taking a nap.
It is not risk free, precisely because of the anesthesia, so in most areas one can only get it if they try enough other treatments - like 2 or 3 or something like that, ideally from different classes of drugs. But definitely do consider this if you're suffering and nothing seems to help (enough).
My great friend, when we were 20, shot himself in the head while we were doing shrooms. This is not an uncommon occurrence. Thousands of incidents of self harm happen every year in the US alone because of these drugs.
I would advise anyone against this. Don't believe the weird hype (that mostly all comes from a few small clicks of people looking to profit off this drug) about mushrooms being some spiritual, mental catch all. If you have any sort of mental illness you probably should avoid. Don't play Russian roulette with your sanity.
Psychedelic therapy is unlikely to ever become mainstream treatment for serious mental illness like schizophrenia or bipolar disorder. In those cases, it’s significantly more likely to cause more problems than it solves. In general these new faddish psychedelic treatments are mostly effective for bougie mental illness – mild depression, anxiety, stress – but they do not belong in a treatment regimen for serious illness. There is a reason every psychedelic treatment study excludes participants with schizophrenia and bipolar.
ECT might seem barbaric and unsexy compared to dosing some psilocybin and listening to some ambient music in a cozy room, but that doesn’t reduce its clinical value for people with serious, treatment resistant disorders.