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jryioyesterday at 10:56 PM3 repliesview on HN

We finally found the first morbidity signal of GLP-1s (or lack thereof).

These are life changing drugs, but like plastic we'll see their effects in force within this generation:

> The longer time spent off GLP-1s, the greater the risk of major cardiovascular events—up to 22 percent for those who abstained for two years.


Replies

stavrosyesterday at 10:59 PM

Doesn't it make sense that, if you were taking a drug that reduces morbidity, you'll get increased morbidity if you stop it?

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cthalupayesterday at 11:33 PM

You are misunderstanding the study (largely because the article heavily misrepresents it, would be my guess)

They do not see an increase against their pre-GLP1 baseline risk - they see a reversal of the cardioprotective benefits the drug provided while they were on it.

TaupeRangeryesterday at 11:47 PM

You failed to understand the results of the study and quoted a passage that does not in any way support your assertion.