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watermelon0today at 5:13 AM0 repliesview on HN

There is a recent one, which shows that the weight was generally stable after 1 year of discontinuation of GLP-1.

> In this cohort study of adults with overweight or obesity who initiated treatment with injectable semaglutide or tirzepatide and discontinued the index medication between 3 and 12 months after initiation, 19.6% restarted the index medication and 35.2% received an alternative treatment in the year after initial treatment discontinuation. The average weight change 1 year after index medication discontinuation was relatively small; however, there was considerable individual-level variability.

https://dom-pubs.pericles-prod.literatumonline.com/doi/10.11...