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vercaemerttoday at 4:06 PM2 repliesview on HN

I worked on the Human Connectome Project.

If they freeze the vesicles that deliver transmitters and make them analyzable, you've got all the information you need. In terms of a modern ANN, it's the connections (axons) and the weights (transmitters/receptors in tandem).

That said, this article doesn't get to the point in the free section. How are they collecting the information? Slicing is inherently destructive. Someone's got to manufacture an entirely novel imaging modality. Perhaps they could scan millimeters ahead of the slice at a resolution high enough to image receptors. Not possible currently.


Replies

roarchertoday at 4:16 PM

> If they freeze the vesicles that deliver transmitters and make them analyzable, you've got all the information you need.

How can we possibly know that the non-connectome details of the brain don't influence computation or conscious experience?

It seems we ignore these only because they don't fit neatly into our piles of linear algebra that we call ANNs.

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cjbgkaghtoday at 4:11 PM

> If they freeze the vesicles that deliver transmitters and make them analyzable, you've got all the information you need. In terms of a modern ANN, it's the connections (axons) and the weights (transmitters/receptors in tandem).

This is exactly what I’m doubting, how can you be so sure?

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