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snissntoday at 3:25 AM1 replyview on HN

I’m digging through the paper. It’s a meta analysis paper.. they have six studies they analyze on anxiety treatment and they (footnotes 40-46) have positive results in terms of cbd showing a significant effect on anxiety reduction. I’m not invested in figuring out exactly how this study came to represent what it claims but it seems like a joke


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snissntoday at 3:35 AM

Ok I see so they have six studies that they found to indicate effective treatment of anxiety with cannibanoids but their meta study only found six trials with 50 people so the significance / n count is not high enough. So the study is a null result ie they don’t have enough data not they’ve disproved it. In fact their data supports the hypothesis. Then the coverage on science daily misrepresented this. Here's citaiton 40: https://www.nature.com/articles/npp20116 "Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients" Pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech. The placebo group presented higher anxiety, cognitive impairment, discomfort, and alert levels when compared with the control group as assessed with the VAMS.