Is that right? Isn't it more related to the fact that people in education/etc. actually drink more coffee for culture reasons but also use their brain more? could that be the actual reason? Because I don't see how all the coffee zombies in my workplace would last longer long term when they're already useless and aggressive today (until they had their coffee)
Coffee, like other beans, is loaded to the hilt with antioxidants, particularly once it’s hyper-concentrated, and the roasting and brewing process eliminates all the mechanisms beans normally use to avoid animals wanting to eat them.
Then again if you have dementia, you are highly likely to lesve the office environment and any study, thus reversing causality.
Isn't this all about brain hypoperfusion coming from some sort of dysautonomia and/or mitochondrial dysfunction and worse blood vessels as we age? We know that medication that helps blood flow and endothelium improves brain long-term, like sildenafil.
Original source: https://jamanetwork.com/journals/jama/article-abstract/28447...
Only a few years ago, there was a study showing that regular caffeine use reduces blood flow to the brain by up to 30%, leading to lower brain volume and increased risk of dementia.
Actual study: https://jamanetwork.com/journals/jama/article-abstract/28447...
”After adjusting for potential confounders and pooling results across cohorts, higher caffeinated coffee intake was significantly associated with lower dementia risk (141 vs 330 cases per 100 000 person-years comparing the fourth [highest] quartile of consumption with the first [lowest] quartile; hazard ratio, 0.82 [95% CI, 0.76 to 0.89]) and lower prevalence of subjective cognitive decline (7.8% vs 9.5%, respectively; prevalence ratio, 0.85 [95% CI, 0.78 to 0.93]).”
So about 18% relative reduction. But if your risks are already low (e.g. active and healthy diet) the relative reduction is less impactful (e.g. 4% to 3.28%).