Speaking from personal experience, Godot has the sneakiest potential. It has all the UI components and flexible layout containers you could ask for, a signaling system that lets you put the methods from less relevant components in the scripts for more relevant ones (making for a more compact project), and you can also manually compile slim template builds for cleaner distribution. There's a future there.
What’s the story for accessibility and non-LTR text boxes?
There are already tools made in Godot, including the godot editor itself. This page has some of them: https://gamefromscratch.com/godot-developed-non-game-applica...