Yep disk space and learning curve are the two major downsides to Nix. The former has never been a problem for me in practice, just run garbage collection once a month. The latter was a big problem, but is now mitigated for most people by LLMs.
Disk space is not an issue as long as you don't try to install the entirety of Texlive.
Disk space is not an issue as long as you don't try to install the entirety of Texlive.