If biology, or some other subject area, is inherently, irredeemably hard to explain, and always will be, then I don't care about it much, because it doesn't mean very much. I care about explanations, not "reality" in the sense of every arbitrary muddle of knotted nerve fibers and confused flour beetles. If all the world's messy, inexplicable things were to gang up and cause us trouble such that we have to pay them attention, we can still ultimately deal with them in the ways that matter by using clarity and the things we can explain well.