I professionally have been helping folks set up and maintain e-Residence and businesses, and all said here in the comments so far tracks: Estonia is absolutely unsurpassed qua administrative ease (this giving you a clear and lasting business advantage), the tax advantages are real, and the jurisdiction only gets better.-
Banking and being scrupulous on your personal taxes at your place of personal residence are issues, but nothing insurmountable, far from it.-
Hopefully the program continues its success and becomes basis for 25th EU regime
I've considered it as a Spanish resident, but don't you have to live six months there to be considered a fiscal resident? Are people regularly operating them from outside Estonia?