alt Hacker NewsThis is very impressive, top labs doing research often don't have experimental designs that are this elaborate. Was the TCR and BCR-seq you conducted helpful to design cell therapies, neoantigen vaccines, and monitor progress?
Given that you carry the HLA-B*27:05 allele, you might have been blessed by being predisposed to a better response. But probably you want to keep an eye on future autoimmunity issues. Talking from experience...
Thanks for the warning, I hope that it wasn't a personal experience for you.
Thanks for the compliment about the elaborate design. I think that when you make something for one or a few patients it is easier to be more elaborate, even with the same knowledge and equipment.
Maybe the TCR and BCR-seq was most helpful for mRNA design and effectiveness monitoring, but hopefully someone else on my team will answer that better.