Fresh should mean creating a new prefix. For example, Proton-GE enabled wow64 in Wine by default, but it requires recreating the prefix to use it. Should be easy enough with Protontricks or even Winetricks.
Yes very much this. It is possible to modify an existing prefix but there are quite a few things to do, it's easier to back up savegames and game config files and then create it anew.
Yes very much this. It is possible to modify an existing prefix but there are quite a few things to do, it's easier to back up savegames and game config files and then create it anew.