alt Hacker NewsMaybe something using AI could be implemented - does a screenshot of your game e.g. every second and if it detects anything that would suggest cheating then it informs some central system and sends it a movie of you playing for the final verdict.
Of course this all is based on the assumption that the local AI can do this fast enough with enough precision.
That runs on client side, so can easily be tampered with (assuming you're suggesting that instead of secure boot chain).
Also cheat HUD elements can be simply rendered outside of game window (or even on another device like smartphone).