These might be theoretical issues that people without experience worry about, but let me share what I've witnessed in practice working almost a decade with Clojure at Nu.

We mostly hired people with no previous Clojure experience. Majority of hires could pick up and get productive quickly. People fresh out of college picked it up faster. I even had a case of employee transitioning careers to S.E., with no previous programming experience, and the language was a non issue.

I can't remember an instance where the language was a barrier to ship something. Due to reduced syntax surface and lack of exotic features, the very large codebase followed the same basic idioms. It was often easy to dive into any part of the codebase and contribute. Due to the focus on data structures and REPL, understanding the codebase was simply a process of running parts of a program, inspecting its state, making a change, and repeat. Following this process naturally lead to having a good test suite, and we would rely on that.

Running on the JVM is the opposite of a problem. Being able to leverage the extensive JVM ecosystem is an enormous advantage for any real business, and the runtime performance itself is top tier and always improving.

The only hurdle I could say I observed in practice was not having a lot of compile time guarantees, but since it was a large codebase anyway, static guarantees would only matter in a local context, and we had our own solution to check types against service boundaries, so in the end it would've been a small gain regardless.