I don't think the syntax is hard to read in any kind of objective sense, it's just different than most mainstream languages. Greek would be hard for me to read too, but that's not because it's necessarily harder to read than English, just that I don't really know Greek.

I agree with the short variable name convention, that's annoying and I wish people would stop that.

Everyone complains about a lack of type safety, but honestly I really just don't find that that is as much of an issue as people say it is. I dunno, I guess I feel like for the things I write in Clojure, type issues manifest pretty early and don't really affect production systems.

The clearest use-case I have for Clojure is how much easier it is to get correct concurrent software while still being able to use your Java libraries. The data structures being persistent gives you a lot of thread safety for free, but core.async can be a really nice way to wrangle together tasks, atoms are great for simple shared memory, and for complicated shared memory you have Haskell-style STM available. I don't remember the last time I had to reach for a raw mutex in Clojure.

Good concurrency constructs is actually how I found Clojure; I was looking for a competent port of Go-style concurrency on the JVM and I saw people raving about core.async, in addition to the lovely persistent maps, and immediately fell in love with the language.

Also, I really don't think the JVM is a downside; everyone hates on Java but the fact that you can still import any Java library means you're never blocked on language support. Additionally, if you're willing to use GraalVM, you can get native AOT executables that launch quickly (though you admittedly might need to do a bit of forward-declaration of reflection to get it working).