From the perspective of PC building, I've always thought it would be neat if the CPU/storage/RAM could go on a card with a PCIe edge connector, and then that could be plugged into a "motherboard" that's basically just a PCIe multiplexer out to however many peripheral cards you have.
Maybe it's gimmicky, but I feel like you could get some interesting form factors with the CPU and GPU cards sitting back-to-back or side-by-side, and there would be more flexibility for how to make space for a large air cooler, or take it up again if you've got an AIO.
I know some of this already happens with SFF builds that use a Mini-ITX motherboard + ribbon cable to the GPU, but it's always been a little awkward with Mini-ITX being a 170mm square, and high end GPUs being only 137mm wide but up to 300mm in length.
That's basically what S-100 systems were, isn't it (on a much slower bus)?
This was (is?) done - some strange industrial computers for sure and I think others, where the "motherboard" was just the first board on the backplane.
The transputer b008 series was also somewhat similar.
Oh, going back to a backplane computer design? That could be cool, though I assumed we moved away from that model for electrical/signaling reasons? If we could make it work, it would be really cool to have a system that let you put in arbitrary processors, eg. a box with 1 GPU and 2 CPU cards plugged in