The air filtration will actually help spread aerosols because air currents will carry them through the cabin before they're captured by a filter.
A high power "eliminate aerosols" mode would be one of those infrastructure things that need to be designed (and tested). Even then a single compartment spacecraft like the Orion or Dragon wouldn't have anywhere for the crew to bivouac while some aerosol evacuation mode was active. So you'd want a whole procedure designed around it.
Part of the need for the Apollo Constant Wear Garments was to make up for the lack of faculties in the command module and LEM. Such a thing would be impractical for a long duration mission so toilets (and waste disposal in general) need to be a reliably solved problem.
Good points. A few hot takes:
> The air filtration will actually help spread aerosols because air currents will carry them through the cabin before they're captured by a filter.
The toilet facilities could have input / suction into the air filtration system. Maybe wise anyway.
> A high power "eliminate aerosols" mode would be one of those infrastructure things that need to be designed (and tested).
I expect the technology is mature in industrial settings, though of course that is much different than microgravity and the constrained resources of the spacecraft. Maybe it exists on the space station? That context still seems significantly different.
> a single compartment spacecraft like the Orion or Dragon wouldn't have anywhere for the crew to bivouac
In their spacesuits, though their exteriors may need decontamination. Maybe they just go outside, though probably not a great idea to have the entire crew outside the spacecraft simultaneously! Maybe in an emergency.
I could imagine the belters in The Expanse just throwing on suits and venting. Of course that only works if you have a bunch of canned air or something that makes it by cracking minerals on board.