On reflection I think it's possible I may have missed the potential positive value of the post a bit. Maybe analyzing pandas gets you down to a set of data frame primitives that is helpful to build any API. Maybe the API you start with doesn't matter. I don't know. When somebody works hard to make something original, you should try to see the value in it, even if the approach is not one you would expect to be helpful.
I stand by my warnings against using pandas as a foundation for thinking about tabular data manipulation APIs, but maybe the work has value regardless.