We're not really calorie constrained anymore and most humans live in much denser environments than they used to. You would expect rate of exposure, the rate of mutation / change and the rate at which new pathogens appear to be higher than in the past.
Consequently, you wouldn't necessarily expect ancestral "defaults" to be optimal for modern environments.
>We're not really calorie constrained anymore
Why do you bring this up? It seems a weird hypothesis to bring up given that the parent comment did not suggest the possibility...
> you wouldn't necessarily expect ancestral "defaults" to be optimal
I like the term ancestral defaults and indeed, we've come a long way since then and our biological and environmental reality is substantially different.
There is this book series Mortal Coil by Emily Suvada which imagines a future where technology has advanced enough to allow one to tweak their genome as easily as we use apps on our phone today. It was a fascinating read.