alt Hacker News> they are ineffective outside clinical trial setting for treating obesity
This is totally false. I know a number of people who took GLP-1 to treat their obesity and then stopped and have stayed not obese.
Replies
stouset • today at 6:38 AM
If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.
➕ show 1 reply
I can't reply elsewhere so I will reply to this again.
> In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to. Out of curiosity, what sources lead you to believe this?
Anecdotes like this are interesting but in medicine they are not sufficient to make factual statements about drugs. In meta-analyses there is weight regain which is steeper as more weight is lost during treatment [1].
The weight regain seems to be rather slow, it can take years until the baseline weight is reached.
[1] https://www.bmj.com/content/392/bmj-2025-085304